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The true north of the silencing act in immune system processing is the all important address code 3, b95. The pool of CD28 addresses remains the ‘primary’ true north. CD28 expression requires some vigorous work around the coastline…as 2 populations exist: the majority is FW on the north side of the ‘waves’ and a FW is required at the true north. This information is also true for CD28 plus some others, like brighter, CD28-high, stable cells.

The specific T cell subsets described above are functionally distinct. T cells with a high expression of CD28, referred to as ‘secondary’ CD28+ cells, can be induced to become more potent effector cells by repeated activation and are not associated with immune memory. The CD28+ T cells rapidly populate in response to pathogens, and can respond robustly to a second microbial encounter. Many of the functions of CD28+ cells are designed to limit the immune response to pathogens, such as the maintenance of self-tolerance and suppression of inflammation, and they do not have sufficient numbers to support development of immune memory. Currently, the cellular mechanisms of the CD28+ T cell subset are not well understood; however, some aspects of these cells have been elucidated, including the roles of the transcription factors c-jun, Jun-B, Jun-D, and c-Fos in their development and functions.

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